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Propolis

Bee "glue" with genuine antimicrobial punch — best evidence for cold sores and oral health.

Reviewed by Bodil Isaksson, Licensed Biomedical Scientist (Sweden)Last reviewed July 2026Food guide

FoodsBee productsImmuneDental

Propolis is the resinous mixture honeybees make to seal and sterilise their hive. It’s rich in flavonoids and has some of the better clinical evidence among bee products.

Key takeaways

  • A flavonoid-rich resin with antibacterial, antiviral and anti-inflammatory activity.
  • Topical propolis helps cold sores (HSV) — some trials rival aciclovir for healing.1
  • It reduces dental plaque and gum inflammation as a mouthwash/adjunct.2
  • Main risk is allergy (contact dermatitis, especially in bee-product-allergic people).

What it is

Propolis is collected plant resin blended with bee wax and enzymes. Composition varies by region, but the active antimicrobial compounds are largely flavonoids and phenolic acids.

Cold sores (HSV)

In several randomised trials, topical propolis sped healing of herpes cold sores, in some comparisons performing as well as or better than aciclovir.1 Propolis lip balms/creams are a reasonable natural option at the first tingle.

Oral health

Meta-analysis supports propolis (as a mouthrinse or gel) for reducing dental plaque and gingival inflammation,2 and it’s used supportively for mouth ulcers/mucositis.

Safety & use

Generally safe, but allergic reactions are the key caution — avoid if you react to bee products, and patch-test topicals. Available as tinctures, sprays, lozenges, creams and toothpaste.

Bottom line: the best-evidenced bee product — a solid natural choice for cold sores and gum health, with allergy the main thing to watch.

References

Educational summary, not a prescription.

  1. Propolis for herpes simplex (cold sore) lesions — clinical trials review. www.medicalnewstoday.com
  2. Propolis as a natural remedy in reducing dental plaque and gingival inflammation: a systematic review and meta-analysis. 2024. pmc.ncbi.nlm.nih.gov

This article summarises nutrition science for education and is not a substitute for individual medical advice.